Powered by the Rhythm360 AI Algorithm to Restore Atrial Rhythm and Mechanical Function
(Atrial Kick)

The Unmet Need

Atrial fibrillation (AF) is increasingly recognized not merely as an electrical disorder, but as a manifestation of progressive atrial disease. As atrial structure and function deteriorate, coordinated atrial contraction is lost, atrial transport (“atrial kick”) diminishes, ventricular filling becomes impaired, and hemodynamics worsen — accelerating the burden of heart failure (HF).

Restoring sinus rhythm alone is insufficient if atrial mechanical function is not also restored. Without effective atrial contraction and synchrony, cardiac output remains compromised and the underlying disease process continues.

AF and HF now coexist in a substantial and growing portion of patients, yet no chronic device-based therapy is designed to directly restore atrial function in addition to rhythm. This therapeutic gap contributes to recurrent hospitalizations, declining functional capacity, and poor long-term outcomes.

Current Approaches

Existing treatment strategies are reactive and focus on symptom control or rhythm suppression, but leave a fundamental problem unresolved:

• Pharmacologic therapies manage rate or rhythm without restoring atrial mechanics.

• Ablative approaches are acute, symptom-directed therapies that can reduce arrhythmia burden; however, atrial fibrillation ablation is fundamentally a rhythm control strategy for symptom relief and does not restore intrinsic atrial pump function. These interventions may therefore come at the expense of atrial tissue integrity and mechanical performance.

As a result, atrial dysfunction persists—and frequently progresses.

Why the Atrium, and Why Now

Loss of effective atrial contraction has significant consequences for cardiac efficiency, ventricular filling, and long-term cardiovascular performance. Addressing both atrial rhythm and mechanical function represents a substantial and largely underexploited opportunity to improve outcomes in patients with atrial fibrillation (AF) and heart failure (HF).

CRT-A

CRT-A™, powered by the Rhythm360™ algorithm, is an investigational, tissue-preserving cardiac rhythm therapy platform designed to restore and maintain functional sinus rhythm while preserving and supporting atrial mechanical contribution.

The system introduces a new category of Cardiac Resynchronization Therapy for the Atrium (CRT-A)—a non-destructive, physiology-guided approach intended to synchronize atrial activation, stabilize rhythm, and maintain atrial transport function rather than ablate or electrically isolate tissue.

By rethinking atrial fibrillation as both a rhythm disorder and a disease of atrial dysfunction, CRT-A seeks to establish a new therapeutic pathway for patients who are inadequately served by pharmacologic therapy or conventional ablation strategies.