Powered by the Rhythm360 AI Algorithm to Restore Atrial Rhythm and Mechanical Function (Atrial Kick)

The Unmet Need

Atrial fibrillation (AF) is increasingly recognized not merely as an electrical disorder, but as a manifestation of progressive atrial disease. As atrial function deteriorates, coordinated contraction is lost, hemodynamics worsen, and the burden of heart failure (HF) accelerates.

AF and HF now coexist in a substantial and growing portion of patients, yet no chronic device-based therapy is designed to directly address atrial dysfunction itself. This gap contributes to recurrent hospitalizations, declining functional capacity, and poor long-term outcomes.

Current Approaches

Existing treatment strategies are reactive and focus on symptom control or rhythm suppression, but leave a fundamental problem unresolved:

• Pharmacologic therapies manage rate or rhythm without restoring atrial mechanics.

• Ablative approaches are acute therapy and can reduce arrhythmia burden, but often at the cost of atrial tissue integrity and mechanical performance.

As a result, atrial dysfunction persists—and frequently progresses.

Why the Atrium, and Why Now

Loss of effective atrial contraction has meaningful consequences for cardiac efficiency, ventricular filling, and long-term performance. Addressing atrial rhythm and function represents a significant, largely untapped opportunity to change outcomes in both AF and HF populations.

CRT-A

CRT-A powered by the Rhythm360 algorithm is an investigational, tissue-preserving cardiac rhythm therapy platform designed to support functional sinus rhythm while maintaining atrial mechanical contribution. The system introduces a new category of Cardiac Resynchronization Therapy for the Atrium (CRT-A)—a non-destructive approach intended to work with atrial physiology rather than replace or remove it.

By rethinking how atrial rhythm and function are managed, CRT-A aims to open a new therapeutic pathway for patients not well served by today’s options.