Cardiac Resynchronization Therapy for the Atrium (CRT-A)
Rhythm360: Restoring Rhythm and Atrial Function
The Unmet Need: AF-HF Is a Progressive Atrial Disease Without a Long-term Solution
Atrial fibrillation (AF) isn’t just an irregular heartbeat — it often develops because the atria themselves become progressively diseased over time.
AF and heart failure (HF) frequently coexist and now account for nearly half of all HF presentations — yet no approved chronic device-based therapy directly targets the underlying atrial disease.
Atrial dysfunction is a hidden driver of HF progression, fueling AF burden, repeat hospitalizations, and increased mortality.
Current therapies fall short:
Medications can slow the rate or modify symptoms, but they cannot restore atrial mechanics or reverse atrial deterioration.
Ablation can reduce arrhythmia burden, but it often leaves the atria electrically and mechanically impaired, failing to address the root cause of AF-HF: atrial dysfunction.
Why the Atrium — and Why Now
AF-HF is fundamentally a disease of atrial dysfunction.
Loss of coordinated atrial contraction elevates left-atrial pressure, impairs ventricular filling, and worsens exercise tolerance and survival.
Addressing atrial function early may prevent irreversible remodeling—preserving both rhythm and cardiac efficiency.
Clinical evidence is clear:
Atrial dysfunction doubles hospitalization and mortality risk in HFpEF patients.【Reddy et al., JACC Heart Fail, 2023】
Reduced LA strain predicts poor outcomes and persistent congestion despite sinus rhythm restoration.【Freed et al., Eur Heart J, 2022】
Post-ablation LA strain abnormalities persist, driving AF recurrence and incomplete hemodynamic recovery.【Park et al., Heart Rhythm, 2021】
No approved therapy exists to restore atrial synchrony or function in AF-HFpEF.
Rhythm360™: Intelligent, Multi-Mode CRT-A
Rhythm360 is an investigational, implantable system designed to restore and maintain atrial function through non-destructive, closed-loop electrical therapy.
Programmable modes addressing the full spectrum of atrial rhythm disorders:
Prevention – Detects and suppresses AF triggers.
Sinus Rhythm Restoration – Imperceptibly AF termination without ablation or shocks.
BBp (Bachmann’s Bundle pacing) – Re-synchronizes atrial contraction and improves AV coordination.
Together, these adaptive modes deliver continuous, intelligent Cardiac Resynchronization Therapy for the Atrium (CRT-A) — supporting sinus rhythm, preserving atrial transport, and potentially altering the trajectory of AF-HFpEF.
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Exciting News from MaxWell Biomedical!
Maxwell Biomedical is expanding its ongoing clinical study to further validate the groundbreaking Spatial Resynchronization Therapy (SRT) for patients with atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF).
SRT is designed to imperceptibly terminate AF and restore atrial function and atrial synchrony —a non-destructive, next-generation approach that sets it apart from conventional ablation therapies. With this expansion, we aim to accelerate clinical insights, broaden patient access, and drive a paradigm shift in AF treatment for the AF-HFpEF population.
Why It Matters:
· Better Outcomes – SRT enhances atrial heart function while preventing AF, addressing a critical unmet need.
· Expanded Study Scope – More patients, more data, stronger clinical validation.
· Innovative Non-Destructive Approach – Unlike ablation, SRT does not destroy cardiac tissue but restores atrial conduction.
As we take this next step, we’re grateful for our investors, clinical partners, and dedicated team members working to bring a new era of AF treatment to patients worldwide.
Stay tuned for more updates!
March 13, 2025
Cardiac Resynchronization Therapy for the Atrium (CRT-A
First Device Approach That Overcomes Past Limitations
Maximum Wellness
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Decades of AF Treatment Have Focused Soley on Tissue Destruction
Medicine Evolves: 🟥 Cox-Maze Surgery (1980s) →🟧 Catheter Ablation (1990s–Present) →🟩 Non-destructive (Future)